Publications

October 22, 2024

Poster Presentation at ESGCT 2024

AnelloVector(TM) Viral Vectors: encapsidating anellovirus-based vectors beyond the wild type genome capacity and demonstrating 12-month durable expression of an eGFP transgene post subretinal administration

Cato Prince, George Bounoutas, Bolu Zhou, Waseem Raja, Isabella Gold, Rianna Pozsgai, Parmi Thakker, Nicole Boisvert, Christopher Reardon, Stephanie Thurmond, Erin Ozturk, Emily Stead, Rajendra Boggavarapu, Simeon Springer, Lovepreet Chahal, Maciej Nogalski, Tuyen Ong, Christopher Wright, Ashley Mackey, Geoffrey Parsons, Joseph Cabral

August 22, 2024

Nature Communications

Structure of anellovirus-like particles reveal a mechanism for immune evasion

Shu-hao Liou, Rajendra Boggavarapu, Noah R. Cohen, Yue Zhang, Ishwari Sharma, Lynn Zeheb, Nidhi Mukund Acharekar, Hillary D. Rodgers, Saadman Islam, Jared Pitts, Cesar Arze, Harish Swaminathan, Nathan Yozwiak, Tuyen Ong, Roger J. Hajjar, Yong Chang, Kurt A. Swanson & Simon Delagrave

May 16, 2024

Oral Presentation at ASGCT 2024

Anellovectors, a Gene Delivery Platform Based on Commensal Human Anelloviruses, Have the Potential to Evade the Immune System and Deliver DNA Payloads to a Broad Range of Tissues in a RedosableMannerAnellovectors, a Gene Delivery Platform Based on Commensal Human Anelloviruses, Have the Potential to Evade the Immune System and Deliver DNA Payloads to a Broad Range of Tissues in a Redosable Manner

Chris Wright

May 8, 2024

Poster Presentation at ASGCT 2024

Anellovector Derived from Human Retinal Pigment Epithelium Delivers and Expresses a Therapeutically Relevant DNA Payload in the Retina of Nonhuman Primates

Parmi Thakker, Alex Auld, Vimal Vaidya, Nolan Sutherland, Maciej Nogalski, Waseem Raja, Isabella Gold, Riana Poszgai, Hyun Jung Jun, Geoffery Parsons, Tuyen Ong, Ashley Mackey, Chris Wright

May 8, 2024

Poster Presentation at ASGCT 2024

Anellovectors: Expanding the payload capacity of anellovirus-based vectors beyond the wild-type genome capacity

Cato Prince, Nicole Boisvert, Silin Liu, Simeon Springer, Lovepreet Chahal, Rajendra Boggavarapu, Waseem Raja, Chris Reardon, Emily Stead, Tuyen Ong, Geoffrey Parsons, and Joseph Cabral

March 30, 2024

Pre-print publication in biorxiv

A novel functional gene delivery platform based on a commensal human anellovirus demonstrates transduction in multiple tissue types

Cato Prince, George Bounoutas, Bolu Zhou, Waseem Raja, Isabella Gold, Rianna Pozsgai, Parmi Thakker, Nicole Boisvert, Christopher Reardon, Stephanie Thurmond, Erin Ozturk, Rajendra Boggavarapu, Simeon Springer, Lovepreet Chahal, Maciej Nogalski, Tuyen Ong, Dhananjay Nawandar, Christopher Wright, Ashley Mackey, Geoffrey Parsons, Joseph Cabral

October 24, 2023

Poster Presentation at ESGCT 2023

AnelloBricks: a novel, cell-free, in vitro assembled viral vector system based on commensal anellovirues offers a highly modular, versatile, low COGs and scalable manufacturing platform solution to genetic medicines

Erik C Hansen, Yue Zhang, Bryan McGuffie, Gwen Buel, Timsi Rao, Alycia Bittner, Rajendra Boggavarapu, Christine Doan, Alexandra Hagner, Eli Miller, Ethan LaFrance, Alison Deng, Lynn Zeheb, Nidhi Mukund Acharekar, Simeon Springer, Cesar Arze, Connor Smith, Vimal Vaidya, James Troia, Matthew Lesher, Jake Matte, Alex Censullo, Amy Correia, Ritika Garg, Duy Nguyen, Hyun Jung Jun, Ye-Rim Kwon, Lianna Swanson, George Bounoutas, Ashley Mackey, Steve Duguay, Kurt Swanson, Chris Wright, Konstantin Konstantinov, Yong Chang, Tuyen Ong, Jodi Kennedy

October 24, 2023

Poster Presentation at ESGCT 2023

Anellovectors: a novel functional gene delivery platform based on commensal human anelloviruses demonstrates transduction in multiple cell and tissue types

Joseph Cabral, Cato Prince, Erin Ozturk, George Bounoutas, Waseem Raja, Bolu Zhou, Nolan Sutherland, Parmi Thakker, Jivanna Mason, Riana Pozsgai, Isabella Gold, Alex Auld, Dinesh Verma, Ruchita Nair, Alex Letizia, Simeon Springer, Lovepreet Chahal, Nicole Boisvert, Gowtham Jayakumar, Rajendra Boggavarapu, Matt Lesher, Alex Censullo, Samson Karben, Gabrielle Feig, Vimal Vaidya, Kurt Swanson, Cesar Arze, Maciej Nogalski, Bryan Vought, Dhananjay Nawandar, Ashley Mackey, Yong Chang, Tuyen Ong, Geoffrey Parsons

July 2, 2022

Pre-print publication in biorxiv

Anellovirus Structure Reveals a Mechanism for Immune Evasion

Shu-hao Liou, Noah Cohen, Yue Zhang, Nidhi Mukund Acharekar, Hillary Rodgers, Saadman Islam, Lynn Zeheb, Jared Pitts, Cesar Arze, Harish Swaminathan, Nathan Yozwiak, Tuyen Ong, Roger J. Hajjar, Yong Chang, Kurt A. Swanson, Simon Delagrave

May 17, 2022

Poster Presentation at ASGCT 2022

Deep Immune Profiling of Candidate Endogenous Anellovirus Gene Therapy Vectors

Harish Swaminathan, PhD, Thiagarajan Venkataraman, PhD, Cesar A. Arze, Sarah M. Jacobo, PhD, Agamoni Bhattacharyya, Tyler David, Dhananjay M. Nawandar, PhD, Simon Delagrave, PhD, Vinidhra Mani, PhD, Nathan L. Yozwiak, PhD, H. Benjamin Larman, PhD

May 18, 2022

Poster Presentation at ASGCT 2022

A Novel Gene Delivery Vector with Low Pre-Existing Immunity in Humans

Dhananjay Nawandar, Joseph Timpona, Nicole Boisvert, Fernando Diaz, Kevin Lebo, Stephanie Thurmond, George Bounoutas, Ashley Mackey, Parmi Thakker, Robert Fusco, Roger Hajjar, Erica Weistein, Yann Echelard, Tuyen Ong, Yong Chang, Avak Kahvejian, Simon Delagrave

April 28, 2022

Pre-print publication in biorxiv

Human anelloviruses produced by recombinant expression of synthetic genomes

Dhananjay M. Nawandar, Maitri Trivedi, George Bounoutas, Kevin Lebo, Cato Prince, Colin Scano, Nidhi Agarwal, Erin Ozturk, Jason Yu, Cesar A. Arze, Agamoni Bhattacharyya, Dinesh Verma, Parmi Thakker, Joseph Cabral, Shu-Hao Liou, Kurt Swanson, Harish Swaminathan, Fernando Diaz, Ashley Mackey, Yong Chang, Tuyen Ong, Nathan L. Yozwiak, Roger J. Hajjar, Simon Delagrave

December 20, 2022

Cell Reports

Comprehensive profiling of antibody responses to the human anellome using programmable phage display

Thiagarajan Venkataraman, Harish Swaminathan, Cesar A. Arze, Sarah M. Jacobo, Agamoni Bhattacharyya, Tyler David, Dhananjay M. Nawandar, Simon Delagrave, Vinidhra Mani, Nathan L. Yozwiak, H Benjamin Larman

October 19, 2021

Poster Presentation at ESGCT 2021

Anelloviruses are highly diverse, ubiquitous commensal denizens of the human virome, and show promising properties as novel gene delivery vectors

D.M. Nawandar, C.A. Arze, J. Timpona, N. Boisvert, M. Trivedi, F. Diaz, K. Lebo, C. Prince, C. Scano, S. Springer, G. Bounoutas, R. Fusco, G. Dudas, S. Patel, A. Bharttacharyya, H. Swaminathan, S. Liou, K. Swanson, T. Ong, A. Kahvejian, Y. Echelard, E.G. Weinstein, R.J. Hajjar, K.G. Andersen, S. Delagrave, N.L. Yozwiak

July 27, 2021

Cell Host & Microbe

Global Genome Analysis Reveals a Vast and Dynamic Anellovirus Landscape within the Human Virome

Cesar A. Arze, Simeon Springer, Gytis Dudas, Sneha Patel, Agamoni Bhattacharyya, Harish Swaminathan, Carlo Brugnara, Simon Delagrave, Tuyen Ong, Avak Kahvejian, Yann Echelard, Erica G. Weinstein, Roger J. Hajjar, Kristian G. Andersen, Nathan L. Yozwiak

Anelloviruses are common in most people, and by developing technologies to map the anellome in humans, we can study their diversity and persistence in blood transfusion recipients. Learn more about our transfusion study from Ring scientists, published in Cell Host & Microbe.